Complementary Symmetry Nanowire Logic Circuits: Experimental Demonstrations and in Silico Optimizations

Complementary symmetry (CS) Boolean logic utilizes both p- and n-type field-effect transistors (FETs) so that an input logic voltage signal will turn one or more p- or n-type FETs on, while turning an equal number of n- or p-type FETs off. The voltage powering the circuit is prevented from having a direct pathway to ground, making the circuit energy efficient. CS circuits are thus attractive for nanowire logic, although they are challenging to implement. CS logic requires a relatively large number of FETs per logic gate, the output logic levels must be fully restored to the input logic voltage level, and the logic gates must exhibit high gain and robust noise margins. We report on CS logic circuits constructed from arrays of 16 nm wide silicon nanowires. Gates up to a complexity of an XOR gate (6 p-FETs and 6 n-FETs) containing multiple nanowires per transistor exhibit signal restoration and can drive other logic gates, implying that large scale logic can be implemented using nanowires. In silico modeling of CS inverters, using experimentally derived look-up tables of individual FET properties, is utilized to provide feedback for optimizing the device fabrication process. Based upon this feedback, CS inverters with a gain approaching 50 and robust noise margins are demonstrated. Single nanowire-based logic gates are also demonstrated, but are found to exhibit significant device-to-device fluctuations

Diet Shapes Mortality Response to Trauma in Old Tephritid Fruit Flies.

Despite the importance of trauma in healthspan and lifespan in humans as well as in non-human species, with one important exception the literature in both gerontology and ecology contains virtually no experimental demographic studies concerned with trauma in any species. We used dietary manipulation [full diet (F) versus sugar-only (S)] to produce four levels of frailty in 55-day old tephritid fruit flies (Anastrepha ludens) that were then subject to the trauma of cage transfer stress (n = 900/sex in each of the 4 treatments). The key results included the following: (1) there is a trauma effect caused by the transfer that depends on previous diet before transfer, new diet after transfer and gender of the fly; (2) males are more vulnerable than females; (3) if initial diet was F, flies are relatively immune against the trauma, and the subsequent diet (F or S) does not matter; (4) however if initial diet was S, then the effect of the trauma depends largely on the diet after the transfer; (5) flies transferred from S to F diets do very well in terms of remaining longevity (i.e. greatest remaining longevity), while flies transferred from S to S diet do poorly (i.e. shortest remaining longevity). We discuss both the strengths and weaknesses of this study and implications of the results

Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4

The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair. Toll-like receptor 4 (TLR4) is a member of a highly conserved receptor family and is a critical activator of the innate immune response after tissue injury. TLR4 signaling has been shown to regulate the systemic inflammatory response induced by exposed bone components during long-bone fracture. Here we tested the hypothesis that TLR4 activation affects the healing of calvarial defects. A 1.8 mm diameter calvarial defect was created in wild-type (WT) and TLR4 knockout (TLR4-/-) mice. Bone healing was tested using radiographic, histologic and gene expression analyses. Radiographic and histomorphometric analyses revealed that calvarial healing was accelerated in TLR4-/- mice. More bone was observed in TLR4-/- mice compared to WT mice at postoperative days 7 and 14, although comparable healing was achieved in both groups by day 21. Bone remodeling was detected in both groups on postoperative day 28. In TLR4-/- mice compared to WT mice, gene expression analysis revealed that higher expression levels of IL-1β, IL-6, TNF-α,TGF-β1, TGF-β3, PDGF and RANKL and lower expression level of RANK were detected at earlier time points (≤ postoperative 4 days); while higher expression levels of IL-1β and lower expression levels of VEGF, RANK, RANKL and OPG were detected at late time points (> postoperative 4 days). This study provides evidence of accelerated bone healing in TLR4-/- mice with earlier and higher expression of inflammatory cytokines and with increased osteoclastic activity. Further work is required to determine if this is due to inflammation driven by TLR4 activation. © 2012 Wang et al

The Electronic Properties of Ni(PNN) Pincer Complexes Modulate Activity in Catalytic Hydrodehalogenation Reactions

Three chloronickel(II) complexes of PNN‐ pincer ligands with pyrazolyl and diphenylphosphino donors appended to different arms of diarylamido anchors were prepared and fully characterized. The three derivatives (1‐OMe, 1‐Me, 1‐CF3) differ only by the identity of the para‐aryl substituent on the pyrazolyl arm with 1‐OMe being 310 mV easier to oxidize than 1‐CF3. All three complexes are competent catalysts for hydrodehalogenation reactions of 1‐bromooctane and a variety of aryl halides in dimethylacetamide using NaBH4 as both base and hydride source. Comparative studies using diverse substrates showed that catalytic activity correlates with electron donor properties; 1‐OMe was superior to the other two. Deuterium labeling studies verified NaBD4 as the deuteride source and excluded solvent‐assisted radical pathways

Estimating the Spatial Distribution of Groundwater Demand In the Texas High Plains

Developing groundwater management plans requires a good understanding of the interdependence of groundwater hydrology and producer water use behavior. While state-of-the-art groundwater models require water demand data at highly disaggregated levels, the lack of producer water use data has held up the progress to meet that need. This paper proposes an econometric framework that links county-level crop acreage data to well-level hydrologic data to produce heterogeneous patterns of crop choice and irrigation practices within a county. Together with agronomic data on irrigation water requirements of various crops and irrigation practices, this model permits estimation of the water demand distribution within a county. We apply this model to a panel of 16 counties in the Southern Texas High Plains from 1972 to 2000. The results obtained not only are consistent with those from the traditional multinomial logit land use model, but also indicate the presence of large intra- and inter-county heterogeneity in producer water use behavior.Discrete Choice Model, Random-coefficients Discrete Choice Model, Crop Choice, BLP, Groundwater, Texas High Plains, Ogallala Aquifer, Crop Production/Industries, Resource /Energy Economics and Policy,

Along-axis gravity gradients at mid-ocean ridges: Implications for mantle flow and axial morphology

Along-axis gradients in mantle Bouguer anomalies (MBAs) were calculated for detailed gravity surveys at the Southwest, Central, and Southeast Indian ridges with half-spreading rates of 0.9, 2.3, and 3.1 cm/yr, respectively. MBA gradients at the very slow spreading Southwest Indian Ridge are 0.4–0.7 mGal/km, similar to the gradients found at the slow-spreading Mid-Atlantic Ridge, whereas gradients at the Central Indian and Southeast Indian ridges are 0.2– 0.35 mGal/km. The results of this study, when combined with other published data, show that axial MBA gradients at ridge segments with an axial high are about 0.1 mGal/km, independent of spreading rate. Gradients at segments with a median valley are higher and generally decrease with increasing spreading rate. The spreading-rate–independent MBA gradient at ridge segments with an axial high represents the mantle gravity signal due to the focusing of upwelling within segments. The larger gravity gradients at segments with an axial valley result from the superposition of intra-segment variations in crustal thickness on this mantle signal. The consistent relation between along-axis MBA gradient and across-axis axial morphology suggests that the axial morphology is related to the efficiency of along-axis transport of melt

Gravity Anomalies, Isostasy, and Mantle Flow at the East Pacific Rise Crest

Bathymetry and gravity data obtained during a detailed Hydrosweep survey of the southern East Pacific Rise from 7°S to 9°S are used to investigate isostasy at the axis of a fast spreading mid-ocean ridge. In particular, we examine the manner in which the bathymetric crestal high is supported and how this support varies along the axis within the 160-km-long 7°12'S-8°38'S ridge segment. The crestal high stands about 400 m above the adjacent ridge flanks and has a nearly constant minimum axial depth for a distance of 140 km. The summit is broad and flat, and an axial summit caldera is present for the entire length of the ridge segment. However, the width and cross-sectional shape of the crestal high vary systematically along the axis. It is broad with gentle slopes in the center of the segment but becomes progressively narrower and steeper toward the ends of the ridge segment. The ridge crest is marked by a free-air gravity anomaly high about 15-20 km wide with an amplitude of 10-15 mGal relative lo the ridge flanks. Mantle Bouguer anomalies vary systematically along the axis with minimum values found near the center of the segment. The axial mantle Bouguer anomalies thus do not reflect the axial depth but are correlated with changes in the cross-sectional area of the crestal bathymetric high. The effects of cooling and subsidence away from the axis were removed from the bathymetry and free-air anomalies to isolate residual topographic and gravity anomalies associated with the ridge crest. The residual crestal bathymetric high was modeled as a flexural feature resulting from the upward buoyant load of a region of low density material centered beneath the axis. The lithosphere was treated as a broken plate, either with a constant flexural rigidity or an effective elastic thickness T, which grows at a rate proportional to the square root of distance from the axis. The best fitting values of T, for the constant rigidity case are in the range of 0.3-0.6 km. For the growing plate model, T, increases at a rate of 0.2-0.3 km1/2. The gravity constrains the mass deficiency to extend to a depth of 20-30 km for both lithospheric models. We interpret this low-density material as a region of partial melt feeding magma to the ridge axis. The best fitting density anomalies imply that a 4 - 9% melt fraction is present beneath the crestal high. Upwelling of melt to the axis is thus confined to a narrow zone within about 10 km of the axis. The mass deficiency and thus the upwelling partial melt are not distributed evenly along the ridge axis but rather are concentrated in the central portion of the ridge segment. It thus appears that differences between the along-axis gravity and depth patterns observed at slow spreading and at fast spreading ridges are not the result of a change from three-dimensional, focused upwelling at slow spreading ridges to two-dimensional sheet-like upwelling at fast-spreading ridges. Rather, the differences in axial gravity and depth between fast and slow spreading ridges reflect differences in the efficiency of the shallow along-axis magma distribution

The Role of Apoptosis in Thyroid Autoimmunity

There is increasing evidence showing that apoptosis plays a role in the development of the autoimmune thyroid diseases—Hashimoto's (lymphocytic) thyroiditis (HT) and Graves' disease (GD). The immune pathogenesis of HT and GD is not yet fully understood, but evidence points toward several steps. A defect in CD4+CD25+ T regulatory cells breaks the immunological tolerance of the host and induces an abnormal production of cytokines, which facilitates the initiation of apoptosis. Though apoptosis appears to play a role in the pathogenesis of both HT and GD, the mechanisms that mediate these processes appear different. The induction of apoptosis in HT results in the destruction of thyrocytes, while apoptosis in the GD leads to damage of thyroid-infiltrating lymphocytes. The differences in the apoptotic mechanisms produce two very different forms of thyroid autoimmune responses, eventually developing into HT and GD, respectively.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63177/1/thy.2007.0208.pd